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                  鄭子龍博士學術報告(6月28日15:00,化西一樓貴賓廳)
                  來源: 作者: 更新時間:2019-06-25

                  報告人:鄭子龍博士

                  報告題目:Routes to N-glycinamideoxazolidinone derivatives: The reaction of 4- trityloxymethyl-3-oxa-1-azabicyclo[3.1.0]hexan-2-one with active halides

                  報告時間:2019628日(周五)下午15:00

                  報告地點:化西一樓貴賓廳


                  報告摘要:

                  N-Glycinamideoxazolidinones are key intermediates for the synthesis of a new class of peptidomimetics. We present herein the synthesis of a series of 3,4,5-trisubstituted oxazolidinones with a glycine residue at N-3 of the oxazolidinone ring. Substituents at C-4 and C-5 contain substitution capabilities which are amenable for the introduction of additional peptide chains. The synthesis of the key N-Glycinamideoxazolidinone is made possible through two reactions; a tandem aziridine ring opening/oxazolidinone alkylation and, subsequently, a fused-lactone ring opening by an amine which leads to the N-Glycinamideoxazolidinones.


                  鄭子龍簡介:

                  2010-2016 美國俄亥俄大學博士,2009-2010 美國德州農工大學考莫斯分校碩士,1999-2003山東大學,本科。鄭子龍博士曾先后在中國科學院上海有機化學研究所麻生明院士課題組,美國普渡大學諾貝爾獎獲得者Negishi教授課題組,美國Promiliad Biopharma Incorporated,巴塞利亞藥業(中國)有限公司從事有機化學研究。鄭子龍博士曾經在J. Am. Chem. Soc., Angew. Chem. Int. Ed.等雜志發表文章8篇,引用約500多次。鄭子龍博士關注教育事業,在留美期間曾資助多名化學,物理,數學專業的本科生赴美攻讀博士學位。


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